Sir Thomas St Leger (executed 8 November 1483) was the second husband of Anne of York (10 August 1439 – 14 January 1476), daughter of Richard Plantagenet, 3rd Duke of York and Cecily Neville. They were married c. 1474.
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Thomas St. Leger was a knight who, very likely was the lover of Anne of York, Duchess of Exeter before their marriage. St. Leger faithfully served Edward IV in both a military and administrative capacity for years. Consequently, Edward IV rewarded St. Leger with a substantial grant of eight manors in the early 1460s.
Anne, Duchess of Exeter had one child with St. Leger, but died during or soon after giving birth to Anne St Leger (14 January 1476 – 21 April 1526). St. Leger never remarried. The couple's daughter eventually married George Manners, 12th Baron de Ros.
Following his wife’s death, St. Leger remained on good terms with his brother-in-law, Edward IV, and served as the king's Controller of the Mint. In 1481, he was granted a license to found a perpetual chantry of two chaplains at the Chapel of St. George in memory of his wife.
Due to the attainder against Anne of York's previous husband, the daughter of Anne and Thomas became the heiress to the Exeter estates. This arrangement was formalized in an Act of Parliament in January 1483.
Not long after Edward IV's brother Richard III ascended the throne in July 1483, St. Leger rebelled when the new king stripped St. Leger of his offices. St. Leger was ultimately captured by Richard III's forces, and executed on 13 November 1483, at Exeter Castle. St. Leger, described by the Crowland chronicler as a "most noble knight," was buried with his wife Anne at Windsor Castle.